Innate immune response: the IN-CAS module

Many drugs interact with our blood, either after injection or uptake via our digestive system. Protein drugs are mostly directly administered via the blood stream, therefore a valid question is: will the drug activate an immune response?

Our immune system keeps us safe against the invasion of harmful agents, such as bacteria, viruses, fungi, and non-human proteins and DNA. The first line of defense is the innate immune response, followed by the production of specific antibodies for long-term protection. One major component of the innate immune response is the complement system, which can be divided in three pathways. One protein (C3) active in all three pathways produces a measurable product, the protein C3a, which acts as a first indicator that the complement system was activated.

We have designed a module, which measures the level of complement activation in human plasma of a drug formulation, either directly applied, or harvested from our protein production module: IN-CAS (in-line complement activation screening). The amount is determined with rapid, single angle SPR based on ELISA* principles.


Module status: designed.


*) ELISA: enzyme-linked immunosorbent assay

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